Generation of reactive oxygen species under experimental stress in mice and its correction

The aim of the work was to study generation reactive oxygen species under experimental stress in mice and their correction. object research were (n=57). In experience «Despair», we studied effect antioxidant Mexidol-Vet® on locomotor activity, duodenal mucosa mice, by leukocytes blood. It found that intramuscular administration a 5 % solution at dose 40 mg/kg/day for 3 days before forced swimming contributes significant increase duration horizontal decrease vertical activity 3.26 times, compared with individuals receiving placebo. model, stress-protective drug Mexidol-Vet established relation adrenal glands, (Pauls index 0.66), «respiratory burst» blood (the maximum intensity light sum chemiluminescence significantly higher than value placebo 233.25 231.28 %, respectively. linear dependence variation kinetics is reflected formula: y= -3020.7x + 10793. significance approximation trend line 0.991.